Company Description

UHN is Canada's #1 hospital and the world's #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN's vision is to build A Healthier World and it's only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

www.uhn.ca

Union: Non-Union
Site: Hydro Place - 700 University Avenue
Department: Research
Reports To: Principal Investigator
Work Model: Hybrid
Job Code: 1673
Hours: 37.5 Hours Per Week
Salary: $18.13 Hourly
Status: Temporary Full-Time
Closing Date: April 25, 2025

Job Summary:

Radio-theranostics is a combination of diagnostics and therapy that uses radio-labelled ligands for targeting tumors. Although the approach has been used for cancer treatment for decades, there is a renewed interest in the treatment modality due to advances in radiochemistry and molecular targeting, as well as recent positive clinical trials in neuroendocrine tumors (NET) and prostate cancer.

The current standard of care uses a 'one size fits all' approach, prescribing a fixed amount of radio-labelled agent to every patient without consideration of patient specific radiation dose to tumors or organs at risk (OAR). Part of the reason for this simplistic approach is the significant resources required for measuring dose. It generally takes multiple (eg. 3) SPECT scans over several days to calculate the absorbed dose to the patient tumours and organs at risk.

There is however, considerable effort in the medical and research community to leverage the absorbed radiation dose to tumors and OAR for personalizing treatment to individual patients. Currently UHN uses an in-house dosimetry platform developed by our group, which was suitable for clinical trials but is not scalable to the increasing demands of standard of care dosimetry for new Health Canada Approved agents such as Pluvicto. There are currently at least two Health Canada approved commercial systems (MIM Sureplan and HERMES Voxelwise Dosimetry) for absorbed dose calculation in radio-theranostics. This project will use existing clinical trial data to compare the workflow and calculated results in absorbed dose between these commercial systems to each other as well as to the existing in-house tool.

We ask that applicants attach a cover letter with their application.

Job Responsibilities:

• Load imaging data clinical trial patients into both systems
• Run tools in the systems to perform segmentation and dosimetry
• Perform image registration manually and by tools in the system
• Create dosimetry reports
• Perform statistical comparison among between systems
• Qualitatively review the ease of use of both systems

• Pursuing an Undergraduate or Master's Degree in a field related to Physics, Medical Physics, Health Sciences, or Biomedical Engineering
• Basic anatomical skills for medical imaging
• Experience with Image Segmentation and Registration
• Experience with statistical analysis
• Basic programing skills (MATLAB)

Why join UHN?

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/)
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.

Vaccines (COVID and others) are a requirement of the job unless you have an exemption on a medical ground pursuant to the Ontario Human Rights Code.

UHN is a respectful, caring, and inclusive workplace. We are committed to championing accessibility, diversity and equal opportunity. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known in advance. Any information received related to an accommodation will be addressed confidentially.

University Health Network thanks all applicants, however, only those selected for an interview will be contacted.

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.